Progress in effects mechanism of piperine on the enhanced bioavailability of drugs

Piperine,a cinnamamide alkaloid,is a naturally occurring compound present as the major active component(1%-9%) in various parts of plants from the family Piperaceae.Several studies have reported the enhancement of bioavailability and improvement of therapeutics of drugs when coadministered with Piperine.In this article,we summarized the advances on mechanism of how Piperine enhance the bioavailability of drugs.