Genetic disruption of the kindlin-3/β1-integrin interaction results in defective β1-integrin dependent platelet adhesion and granula secretion

III 4.3 Platelet characterization 4.4 Integrin activation assays 4.5 Platelet spreading 4.6 Tailbleeding assay 4.7 Carotid ligation assay 4.8 Aggregation assays 4.9 Dense granula and -granula secretion 4.10 Integrin tail phosphorylation 5. Discussion 5.1 1 TTAA integrins 5.1.1 1 TTAA integrin outside-in signaling 5.1.2Integrin tail binding partner 5.1.3Threonine phosphorylation of the integrin tail 5.1.4 1 TTAA expression level 5.2 1 integrins in arterial thrombosis 5.2.1 Bone marrow chimera 5.2.2 Carotid ligation assay and occlusive thrombus formation 5.2.3 Aggregation and secretion 6. Summary 7.