The relationship between sperm DNA fragmentation and male infertility

Objective To explore the relationship between sperm DNA fragmentation rates and male infertility. Methods Case-control study was used. Sperm DNA fragmentation rates were compared between the primary infertile males for unknown reasons(n= 126) and the males whose spouses undergoing delivery in three months(n= 100). Results Sperm DNA fragmentation rate of the research group was(11.95±4.89)%. Sperm DNA fragmentation rate of the control group was(10.07±3.56)%.Significant difference was found between the two groups on sperm DNA fragmentation rate(t=- 3.326,P= 0.001). The 226 men were divided into group A with sperm DNA fragmentation rates<10%(n= 130)and group B with sperm DNA fragmentation rates≥10%(n= 96). The percentage of male infertility in group A was significantly lower than that in group B(50.00% vs 61.62%)(χ2= 4.105,P= 0.043). Conclusion Correlation is found between sperm DNA fragmentation rates and male infertility. Key words: Infertility, Male; DNA fragmentation rate; Spermatozoa