The many faces of two closely related tauopathies : progressive supranuclear palsy and corticobasal degeneration

The five studies forming this thesis deal with two closely related neurodegenerative diseases,progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), both of which are characterised by abundant tau-positive neuronal and glial filamentous inclusions and by \nshared genetic risk factors[19, 70]. Four studies focus on demonstrating neuropathological, biochemical and genetic differences between the classical/typical form and atypical PSP while the fifth study discusses issues relevant for understanding disease progression in CBD. \n