Regioselective Synthesis of 2,3‐Dihydrobenzo[f]isoindolones via Ag‐Catalyzed Sequential Ugi 4CR/Cascade Radical Cyclization Reaction

Abstract An approach to 2,3‐dihydrobenzo[ f ]isoindolones by a Ag‐catalyzed Ugi 4CR/cascade radical cyclization sequence under mild conditions has been developed. The reaction of ( E )‐2‐benzylidene‐4‐arylbut‐3‐ynoic acids, aldehydes, amines, and isocyanides produced 2,3‐dihydro‐benzo[ f ]isoindolones regioselectively in 60–85% yields via sequential Ugi 4CR/cascade radical cyclization reaction in the presence of Cs 2 CO 3 and AgOTf. The method achieved the formation of two C−C bonds under air atmosphere in one‐pot fashion. magnified image