刺激
软骨细胞
体内
细胞生物学
效应器
化学
体外
生物
神经科学
生物技术
生物化学
作者
Guang-Lu Yang,Yang Guo,Pengcheng Tu,Chengjie Wu,Yalan Pan,Yong Ma
标识
DOI:10.7507/1001-5515.202001044
摘要
As a kind of mechanical effector cells, chondrocytes can produce a variety of physical and chemical signals under the stimulation of multiaxial load in vivo, which affect their own growth, development and apoptosis. Therefore, simulating the mechanical environment in vivo has become a research hotspot in the culture of chondrocytes in vitro. Although a large number of reports have fully proved that different mechanical stimulation can regulate the metabolism of chondrocytes, the loading scheme has not been agreed. Starting from different mechanical forms, this review will explore the differences in the regulation of chondrocyte metabolism by different mechanical stimuli, so as to find an advantage scheme to promote the growth and proliferation of chondrocytes and to develop a more stable, effective and reliable experimental strategy.
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