Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague–Dawley rats

Glyphosate and GBHs at exposure levels corresponding to the EU ADI and the EU NOAEL caused dose-related increases in incidence of multiple benign and malignant tumors in SD rats of both sexes. Early-life onset and mortality were observed for multiple tumors. These results provide robust evidence supporting IARC's conclusion that there is "sufficient evidence of carcinogenicity [of glyphosate] in experimental animals". Furthermore, our data are consistent with epidemiological evidence on the carcinogenicity of glyphosate and GBHs.