CoMoO4 Nanosheets-Based Electrochemical Sensing Platform for Voltammetric Determination of Doxorubicin as a Chemotherapeutic Agent

Doxorubicin (DOX) is an anthracycline-derived medication used for its antitumor and antibiotic properties. Measuring DOX levels is important for treatment management, monitoring, and optimizing individual dosages. This work introduced a novel and sensitive electrochemical sensing platform for determination of DOX based on screen-printed carbon electrode (SPCE) modified with CoMoO4 nanosheets (NSs). A simple hydrothermal method was applied to prepare CoMoO4 NSs. Then, the characterization studies of prepared nanosheets were conducted by using field-emission scanning electron microscopy and X-ray diffraction analysis to provide necessary information about the morphological features and crystalline structure. The using of CoMoO4 NSs in the modification of SPCE facilitated the transfer rate of electrons, thereby improving the electrocatalytic performance of SPCE towards the redox process of DOX. This observation was obtained from the cyclic voltammetry studies. Also, on the basis of differential pulse voltammetry analysis for quantitative measurements, a linear calibration curve was obtained within a wide concentration range of DOX from 0.005 to 175.0 μM with a low detection limit of 0.0015 μM. Furthermore, the CoMoO4 NSs/SPCE sensor has been successfully employed in monitoring DOX in the DOX injection and urine sample, which can offer a suitable platform for qualitative analysis of drugs.