Antioxidant nanozymes for prevention of diseased kidney from failure

Oxidative stress is a state of excessive free radicals and is commonly found with diseased kidneys. Therefore, development of antioxidant-based therapy has been of great interest to biomedical scientists for kidney disease management. One of the drawbacks of using natural antioxidants is their low bioavailability, which limits their anti–free radical efficacy. This commentary discusses novel antioxidant gold-platinum nanoparticles and their potential for prevention of kidney failure in patients who are diagnosed with chronic kidney disease. Oxidative stress is a state of excessive free radicals and is commonly found with diseased kidneys. Therefore, development of antioxidant-based therapy has been of great interest to biomedical scientists for kidney disease management. One of the drawbacks of using natural antioxidants is their low bioavailability, which limits their anti–free radical efficacy. This commentary discusses novel antioxidant gold-platinum nanoparticles and their potential for prevention of kidney failure in patients who are diagnosed with chronic kidney disease. Novel gold-platinum nanoparticles serve as broad-spectrum antioxidants for attenuating ischemia reperfusion injury of the kidneyKidney InternationalVol. 102Issue 5PreviewKidney ischemia reperfusion injury (IRI) is a common and inevitable pathological condition in routine urological practices, especially during transplantation. Severe kidney IRI may even induce systemic damage to peripheral organs, and lead to multisystem organ failure. However, no standard clinical treatment option is currently available. It has been reported that kidney IRI is predominantly associated with abnormally increased endogenous reactive oxygen species (ROS). Scavenging excessive ROS may reduce the damage caused by oxidative stress and subsequently alleviate kidney IRI. Full-Text PDF