海绵
化学
圆二色性
对映体
立体化学
绝对构型
消炎药
属
植物
生物
药理学
作者
Dai-Chun Li,Hui-Xian Liang,Xiaojian Liao,Xiwen Xing,Shi‐Hai Xu,Bing‐Xin Zhao
标识
DOI:10.1002/cbdv.202300950
摘要
Two new pairs of enantiomeric butenolides, (+)- and (-)-suberiteslide A, (+)- and (-)-subertieslide B had been obtained from the marine sponge Suberties sp. The structures with absolute configurations of these compounds were unequivocally determined by spectroscopic analyses and ECD (Electronic Circular Dichroism) method. It was the first separation of butenolides from the marine sponges of genus Suberites. Additionally, the anti-inflammatory, antibacterial and cytotoxic activities of these compounds were evaluated. The result indicated that only (-)-subertieslide B showed weak anti-inflammatory activity with the IC50 value of 40.8 μM.
科研通智能强力驱动
Strongly Powered by AbleSci AI