UV-curable semi-interpenetrating anticoagulant matrix for polyester fabric-covered stents

To develop an anticoagulant coating for polyethylene terephthalate (PET) fabric-covered stents, we prepared a series of ultraviolet (UV)-curable coatings with different film-forming compositions and enoxaparin sodium ratios. We then investigated their mechanical properties and hydrophilicity by adhesion, pencil hardness, abrasion resistance tests, and water contact angle measurements. In addition, their biocompatibility and cytotoxicity were evaluated by their protein adsorption, platelet adhesion, and plasma recalcification times, and by CCK-8 assays. Finally, an anticoagulant coating with excellent mechanical properties, biocompatibility, and low cytotoxicity was obtained, offering a feasible scheme for covered stents in clinical practice. • A novel UV-curable semi-interpenetrating anticoagulant coating matrix was designed and prepared. • Enoxaparin sodium was successfully incorporated into the matrix to provide excellent biocompatibility and hemocompatibility. • The coating system is potentially applied in intravascular cover stents for interventional therapy of endovascular diseases.