Xanthogranulomatous Cholecystitis Masquerading as Gallbladder Carcinoma on 68Ga-FAPI-04 PET

Abstract 68 Ga-FAPI-04 has great potential for the detection and staging evaluation of a variety of tumors. We report a case of suspected gallbladder carcinoma that was enrolled in a prospective study of 68 Ga-FAPI-04 imaging at our institution. This case was later histopathologically confirmed as xanthogranulomatous cholecystitis. This demonstrates that xanthogranulomatous cholecystitis might be disguised as gallbladder carcinoma in 68 Ga-FAPI-04 imaging. Thus, we suggest that nuclear clinicians evaluating 68 Ga-FAPI-04 imaging should be aware of this possibility.