Trends in hollow fibre liquid phase microextraction for the preconcentration of pharmaceutically active compounds in aqueous solution: A case for polymer inclusion membrane

Low concentrations of pharmaceutically active compounds have been reported in samples from highly complex aqueous environments. Due to their low concentrations, efficient sample pretreatment methods are needed to clean samples and concentrate the compounds of interest prior to instrumental analysis. Hollow fibre liquid-phase microextraction (HF-LPME) is an effective alternative to conventional techniques such as liquid-liquid extraction (LLE) and solid phase extraction (SPE) because it consumes less organic solvent and is less labour intensive with a short extraction time. HF-LPME involves the preconcentration and mass transfer of target analytes from an aqueous sample into an acceptor solution in the lumen of the fibre using a supported liquid membrane (SLM) impregnated in the hollow fibre pores. However, despite the high contaminant selectivity, reproducibility, and enrichment that HF-LPME offers, this technique is limited by membrane instability. Although several advances have been made to address membrane instability, they are either too costly or not feasible for industrial application. Hence, hollow fibre polymer inclusion membrane liquid-phase microextraction (HF-PIM-LPME) was introduced to ameliorate membrane instability. This new approach uses ionic liquids (ILs) as a green solvent, and has demonstrated high membrane stability, good contaminant enrichment, and similar selectivity and reproducibility to HF-SLM-LPME. Hence, this review aims to raise awareness of HF-PIM-LPME as a viable alternative for the selectivity and preconcentration of pharmaceuticals and other contaminants in aquatic environments.