微泡
材料科学
原子力显微镜
导电体
导电原子力显微镜
电阻率和电导率
纳米技术
电压
电导率
表征(材料科学)
偏压
纳米颗粒
光电子学
复合材料
电气工程
化学
小RNA
物理化学
工程类
基因
生物化学
作者
Yu Zhang,Tuoyu Ju,Mingyan Gao,Zhengxun Song,Hongmei Xu,Zuobin Wang,Ying Wang
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2022-04-29
卷期号:33 (29): 295103-295103
被引量:4
标识
DOI:10.1088/1361-6528/ac4d57
摘要
The physical properties of tumor-derived exosomes have gained much attention because they are helpful to better understand the exosomes in biomedicine. In this study, the conductive atomic force microscopy (C-AFM) was employed to perform the electrical characterizations of exosomes, and it obtained the topography and current images of samples simultaneously. The exosomes were absorbed onto the mica substrates coated with a gold film of 20 nm thick for obtaining the current images of samples by C-AFM in air. The results showed that the single exosomes had the weak conductivity. Furthermore, the currents on exosomes were measured at different bias voltages and pH conditions. It illustrated that the conductivity of exosomes was affected by external factors such as bias voltages and solutions with different pH values. In addition, the electrical responses of low and high metastatic potential cell-derived exosomes were also compared under different voltages and pH conditions. This work is important for better understanding the physical properties of tumor-derived exosomes and promoting the clinical applications of tumor-derived exosomes.
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