碳二亚胺
产量(工程)
胺气处理
化学
盐酸盐
偶联反应
组合化学
联轴节(管道)
反应条件
有机化学
催化作用
材料科学
冶金
作者
Deepak Sehgal,Inder K. Vijay
标识
DOI:10.1006/abio.1994.1144
摘要
Water-soluble carbodiimides are widely used for carboxyl-amine conjugation. However, extremely variable and low yields, obtained under a variety of conditions, have been a serious problem in the coupling. A simple method, optimizing various parameters of the coupling reaction, in which N-hydroxysuccinimide is included to assist the 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride-catalyzed amidation reaction is described. A product yield of up to 90% is routinely achieved.
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