破骨细胞
化学
关节炎
细胞生物学
胶原性关节炎
接头(建筑物)
癌症研究
生物化学
免疫学
生物
体外
结构工程
工程类
作者
Bitnara Lee,Sungsin Jo,Sung Min Kim,Mi La Cho,Sung Hwan Park,Jeehee Youn,Jong Dae Ji,So Yeon Kim
标识
DOI:10.1016/j.imlet.2018.09.004
摘要
Poly-γ-glutamic acid (γ-PGA), a natural polymer derived from Bacillus subtilis, shows anti-inflammatory activity. However, the effects of γ-PGA on osteoclasts, which are important cells for joint destruction in inflammatory diseases such as rheumatoid arthritis (RA), have not yet been reported. In this study, we show that γ-PGA markedly inhibits osteoclast differentiation in normal PBMC-derived osteoclast precursors and in synovial fluid macrophages of patients with RA. γ-PGA also reduces RANK expression by down-regulating M-CSF receptors. Additionally, oral administration of γ-PGA attenuated bone destruction in a collagen-induced arthritis (CIA) model, demonstrating decreases in inflammation, cartilage damage, and osteoclast formation in histological analyses. Taken together, these data suggest that γ-PGA could be a good candidate for therapeutic prevention of joint destruction in RA.
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