Are regional metabolic differences of adipose tissue responsible for different risks of obesity?

Recent research has shown that statistical correlation of disease is usually stronger to abdominal distribution of adipose tissue than to obesity. Abdominal distribution of adipose tissue in women is associated to other male characteristics of muscle tissue mass and morphology, as well as signs of androgenicity in circulating hormones. Abdominal adipose tissue is sensitive to lipolytic stimuli. It might be considered that the endocrine aberrations in combination with elevated concentrations of circulating free fatty acids might cause the complications associated with abdominal obesity.