Synthesis of N-(2-aminophenyl)-2-quinazolinone-acetamide hydrochloride

Four novel N-(2-aminophenyl)-2-quinazolinone-acetamide hydrochloride(1∶1)were synthesized through nucleophilic substitution,hydrogenation and acidification.The nucleophilic substitution was reacted between 2-bromo-N-(2-nitrophenyl)acetamide and various substituted quinazolinone under the catalysis of NaH.Among them,2-bromo-N-(2-nitrophenyl)acetamide was synthesized by a reaction between acetyl chloride and o-nitroaniline.And the substituted quinazolinone was synthesized by using aminobenzoic acid and formamide.The structures of these compounds were confirmed by 1H NMR,IR spectra and HRMS.