内皮干细胞
脐静脉
胶原酶
抗原
人类白细胞抗原
生物
外周血单个核细胞
免疫学
内皮
分子生物学
细胞生物学
体外
生物化学
内分泌学
酶
作者
Henry Hirschberg,Bergh Oj,E. Thorsby
出处
期刊:PubMed
日期:1980-08-01
卷期号:152 (2 Pt 2): 249s-255s
被引量:64
摘要
Human endothelial cells were obtained by collagenase digestion of the umbilical vein wall, explanted into tissue culture, and grown as monolayers of cells. Endothelial cells extracted from these monolayers were specifically lysed by anti-HLA-DR alloantisera. Moreover, the stimulating capacity of these endothelial cells toward allogeneic peripheral blood mononuclear lymphocytes was specifically and significantly inhibited by the presence of relevant anti-HLA-DR antisera. Endothelial cells that expressed HLA-DR determinants were also capable of substituting for macrophages in the lymphoproliferative response of purified T cells to soluble protein antigens. Moreover, in concordance with the results previously reported in which macrophages were employed, the endothelial cell donor should share HLA-DR determinants with the T cell donor for an optimal response to occur.
科研通智能强力驱动
Strongly Powered by AbleSci AI