医学
糖尿病
重症监护医学
截肢
清创术(牙科)
糖尿病足
伤口愈合
败血症
外科
内分泌学
作者
Mesut Okur,Ece Özcan Bülbül,Gökçe Mutlu,Kalliopi Eleftherıadou,Ioannis D. Karantas,Neslihan Üstündağ Okur,Panoraia I. Sıafaka
出处
期刊:Current Drug Targets
[Bentham Science]
日期:2022-03-01
卷期号:23 (4): 393-419
被引量:6
标识
DOI:10.2174/1389450122666210914104428
摘要
Diabetes is a global health problem that has resulted in millions of deaths; one of the most common diabetes complications is that wounds of diabetic patients tend to heal more slowly or may not heal at all, resulting in undesirable outcomes. Diabetic wounds, if become chronic and infected, could provoke lower extremities amputation, sepsis, and even death. Hence, early detection, careful examination, debridement, cleaning, and prevention or controlling the infection of diabetic wounds are important factors for the successful outcome of the case. Over the years, various promising wound dressings incorporating antimicrobial molecules, growth factors, and wound healing agents have been developed, targeting diabetic wounds. Nonetheless, the choice of dressing is mainly based on the experience of each clinician.This review summarizes the main points of diabetes complications, diabetic wounds, and infections. Further, an overview of the current drug delivery systems for topical wound delivery of various active ingredients has been performed. This update could be helpful for scientists and especially clinicians who desire to plan and work with new strategies for the healing of diabetic wounds.
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