明胶
材料科学
复合数
静电纺丝
复合材料
生物医学工程
图层(电子)
脚手架
灵活性(工程)
聚合物
化学
数学
生物化学
医学
统计
作者
Bin Wang,Yi Zhang,Junchao Hu,Yuanyuan Liu
出处
期刊:Journal of physics
[IOP Publishing]
日期:2021-07-01
卷期号:1965 (1): 012030-012030
标识
DOI:10.1088/1742-6596/1965/1/012030
摘要
Abstract Small-diameter artificial vessels require a combination of a range of material properties, including high strength, compliance, sutureability, and kink resistance in specific situations. We combined electrospinning technology with thermally induced separation technology to prepare composite three-layer artificial vessels using a PCL/gelatin co-blended material and a hybrid hydrogel enhanced gel structure to achieve high strength, flexibility and kink resistance, as well as excellent water tightness. The electrospun fibers in the artificial vessel provide mechanical stability, while the gelatin blended material enhances hydrophilicity. The results show that the three-layer composite structure is well bonded together, provides sufficient rupture strength and sutureability, and exhibits arterial-like compliance and resistance to kinking. The hydrogel layer drug release rate can also be adjusted by adjusting the PCL/gelatin co-blended layer ratio. This composite vascular scaffold is expected to play an important role in tissue engineering.
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