调节性B细胞
免疫学
格雷夫斯病
自身免疫性疾病
疾病
免疫系统
医学
甲状腺炎
白细胞介素10
下调和上调
甲状腺
生物
内分泌学
抗体
内科学
遗传学
基因
作者
Shaoyang Kang,Junning Kang,Haitao Shen,Na Wu
标识
DOI:10.1016/j.intimp.2021.107770
摘要
Regulatory B cells (Bregs) are a subset of B cells that can downregulate the immune and inflammatory responses. The development of B cells in humans and mice is differs. The Positioning and targeted regulation of Bregs has a positive effect on autoimmune diseases. Autoimmune thyroid disease (AITD) is a common autoimmune disease. This review introduces the history and origins of Bregs. It summarizes the different phenotypes and functionalities of Breg cells related to AITD and analyzes the reasons for the differences in Breg expression frequencies in Graves disease (GD) and Hashimoto's Thyroiditis (HT). A number of functional defects of regulatory B cells may be the newly discovered cause of AITD. This paper sheds new light on the role and prospects of Bregs in the progression and treatment of AITD.
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