OP0207 ASSOCIATION BETWEEN DEMENTIA AND GOUT: A NATIONWIDE POPULATION-BASED STUDY

Background: Dementia is a common mental illness associated with aging. Alzheimer’s disease (AD) and Vascular dementia (VaD) are the most common causes of dementia in the elderly. In previous studies, hyperuricemia was suggested to have anti-oxidant effects and possible neuroprotective effects [1,2]. Objectives: Hyperuricemia is the most important factor in the pathogenesis of gout. This study aims to investigate association between gout and dementia. Methods: We conducted a nationwide population-based study using the NHIS-NSC database of the Korean populations consisted of 1 million individuals between 2002 and 2013. Gout patients were defined by International Classification of Diseases (ICD)-10 code for gout (M10) and prescriptions for urate lowering therapy including allopurinol, febuxostat and benzbromarone at least 30days. Dementia was also defined by ICD-10 codes for dementia; Alzheimer’s disease (AD; F00), vascular dementia (VaD; F01). Results: Excluded 40 patients with previous diagnosed dementia, total 5,496 gout patients were compared to 27,480 age- and sex-matched control group. The analysis results showed that gout patients had a lower risk of overall dementia [odds ratio (OR): 0.79; 95% confidence interval (CI): 0.63-0.99; p < 0.05] after adjusted for age, sex, household income, comorbidities. The risk of VaD (OR: 0.77; 95% CI: 0.32-1.9; p=0.68) and AD (OR; 0.8; 95% CI: 0.53-1.19; p=0.06) tended to be lower in gout group but these were not significant. Conclusion: Gout patients had a lower risk of dementia. This result tended to exist for both AD and VaD type of dementia. References: [1]Hooper DC, Spitsin S, Kean RB, et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci USA. 1998; 95: 675–80. [2]Bowman GL, Shannon J, Frei B, et al. Uric acid as a CNS antioxidant. J Alzheimer’s Dis. 2010; 19: 1331–6. Disclosure of Interests: None declared