Polysaccharides from Agrocybe cylindracea residue alleviate type 2-diabetes-induced liver and colon injuries by p38 MAPK signaling pathway

In this experiment, we investigated the possible mechanism of polysaccharides from Agrocybe cylindracea residue (PACR) on ameliorating the type-2-diabetes-induced liver and colon injuries. Animal experiments have proved that PACR could reduce the oxidative damage and inflammatory response. Meanwhile, the PACR could restore lipid levels, decrease the level of liver and colon lesions in injured mice, and finally play a role in protecting liver and colon. The results showed that PACR could be used as a supplement to decrease blood glucose and relieve T2DM and reduce oxidative stress and inflammatory response by inhibiting the activation of p38 MAPK signaling pathway.