二乙醇胺
化学
胺化
组合化学
还原胺化
烷基
叠氮化钠
有机化学
催化作用
作者
Hao Yang,Yu Liu,Ruoyun Lin,Zhen Ouyang,Mingli Han,Lijun Zhu,Shizhen Chen,Xin Zhou,Zhong‐Xing Jiang
摘要
Monodisperse oligoethylene glycols (M-OEGs)-containing symmetrical secondary amines are highly valuable synthetic intermediates in drug development and materials sciences. Scalable three-step synthesis of M-OEGs secondary amines with flexible M-OEGs and/or alkyl chains is described herein. Through reduction amination of diethanolamine, Williamson ether synthesis, and subsequent deprotection, a series of M-OEGs secondary amines with diverse and fine-tunable chemical structures were conveniently prepared. The presented strategy is attractive with readily available starting materials, simple catalytic systems, scalable synthesis, and avoids the use of explosive sodium azide.
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