Chrono-pharmacology-based antiplatelet therapy for acute myocardial infarction

Graphical AbstractOpen in new tabDownload slideChrono-pharmacology-based antiplatelet therapy. Mammalian Rev-erbα expression in platelets shows a circadian rhythm and reaches its highest expression at 9 a.m., a time corresponding to the occurrence of major adverse cardiovascular events. Increased Rev-erbα expression leads to an increased platelet aggregation, while both genetic deletion and pharmacological inhibition of Rev-erbα decreased multiple aspects of mouse and human platelet activation. Rev-erbα platelet-specific knockout mice (Plt.-specific Rev-erbα KO mice) have prolonged bleeding time and reduced extent of thrombosis in the ferric chloride-induced thrombosis mouse model and reduced infarct size after experimental acute myocardial infarction.