Photosensitized Peroxidase Mimicry at the Hierarchical 0D/2D Heterojunction‐Like Quasi Metal‐Organic Framework Interface for Boosting Biocatalytic Disinfection

Abstract Metal‐organic frameworks (MOFs) are a versatile toolbox for the bioinspired design of nanozymes for antibacterial applications and beyond, however, designing a nanozyme by the hierarchical quasi‐MOF scheme remains largely unpracticed. This work exemplifies the preferential structure‐activity correlation of a bimetallic quasi‐MOF (Q‐MOF Ce0.5 ) among three series of MOF‐derived peroxidase (POD) mimics. The biomimetic quasi‐MOF Ce0.5 nanosheets accommodate both oxygen vacancy‐coupled multivalent redox cycles and photosensitive energy band layout, benefiting from the hierarchical heterojunction‐like 0D/2D interface featuring isolated nodes‐derived CeOCu sites upon the 2D decarboxylated MOF scaffold. These integrated unique merits enable the POD‐like Q‐MOF Ce0.5 to generate sustained reactive oxygen species to effectively eradicate the surface‐adhered bacteria under visible light, resulting in significant inactivation of Escherichia coli (99.74 %) and Staphylococcus aureus (99.35%) in vitro, and potent disinfection of skin wounds in vivo in safe and on‐demand manners. It is hoped that this work can intensify the interventions of MOF nanozymes against the microbial world.