免疫衰老
医学
免疫系统
免疫学
疾病
衰老
免疫
老年学
内科学
作者
Jack Feehan,Nicholas Tripodi,Vasso Apostolopoulos
出处
期刊:Maturitas
[Elsevier]
日期:2021-05-01
卷期号:147: 7-13
被引量:33
标识
DOI:10.1016/j.maturitas.2021.02.006
摘要
Cellular senescence is a critical part of human anti-tumor defence; however, the accumulation of senescent cells with age underpins a wide range of pathologies. Senescent change in immune cells, or immunosenescence, has a wide range of physiological effects and is at least partially responsible for many diseases associated with aging. Immunosenescence underpins inflammaging, increased vulnerability to infectious disease with age, malignant change in the elderly, and auto-immunity. Understanding the effects and mechanisms of immunosenescence will improve disease outcomes and prevention in older adults, and generate new treatments for common illnesses. In this review we summarize the key changes occurring in immunosenescence across each facet of the immune system, and identify their clinical correlates.
科研通智能强力驱动
Strongly Powered by AbleSci AI