化学
卤素
催化作用
亲核细胞
组合化学
药物化学
基础(拓扑)
有机化学
高分子化学
数学
数学分析
烷基
作者
Thomas R. Puleo,Danielle R. Klaus,Jeffrey S. Bandar
摘要
We report a general protocol for the direct C–H etherification of N-heteroarenes. Potassium tert-butoxide catalyzes halogen transfer from 2-halothiophenes to N-heteroarenes to form N-heteroaryl halide intermediates that undergo tandem base-promoted alcohol substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcohols with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions.
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