The study of the change characteristics of the aircraft fuel tank oil level is of great significance to the flight safety and reliability of the aircraft. Studying the changing characteristics of the aircraft fuel tank oil level can effectively improve the effective range, flight safety and overall performance of the aircraft. At present, there are limitations in the research on the characteristics of aircraft oil tank oil level change and the method of fuel quantity measurement, such as low measurement accuracy and poor stability. This paper presents a new method for researching the oil level change characteristics of aircraft fuel tanks based on Amesim. According to the fuel system configuration, the system simulation of the fuel level change characteristics of wide-body passenger aircraft fuel tanks is divided into two parts: the fuel level change of the fuel tank with super-control configuration Characteristic system simulation, system simulation of fuel tank oil level change characteristic of transfer fuel configuration. For each configuration of the fuel tank fuel level change system simulation, the fuel level change characteristics of each fuel tank are tested under different flight attitudes. During the simulation process, the change of the remaining fuel in each fuel tank of the aircraft is mainly concerned. Compared with the traditional aircraft fuel tank oil level change characteristic research method, the method of fuel tank oil amount change characteristic research has the advantages of intelligence, digitization, high accuracy and high anti-interference, etc., and is of great significance for improving the accuracy of the fuel amount measurement system.