医学
心脏病学
内科学
心房颤动
射血分数
倾向得分匹配
显著性差异
心力衰竭
作者
Quang Tan Phan,Seung Yong Shin,Ik Sung Cho,Wang Soo Lee,Hoyoun Won,Saima Sharmin,Dong Hoon Lee,Tae Ho Kim,Chee Jeong Kim,Sang Wook Kim
出处
期刊:Cardiology Journal
[VM Media Sp zo.o. - VMGroup SK]
日期:2019-11-06
卷期号:26 (5): 519-528
被引量:15
标识
DOI:10.5603/cj.a2018.0047
摘要
Background: Although the safety and efficacy of left atrial (LA) appendage (LAA) closure (LAAC) in nonvalvular atrial fibrillation (NVAF) patients have been well documented in randomized controlled trials and real-world experience, there are limited data in the literature about the impact of LAAC on cardiac remodeling. The aim of the study was to examine the impact of LAAC on cardiac functional and structural remodeling in NVAF patients. Methods: Between March 2014 and November 2016, 47 NVAF patients who underwent LAAC were included in this study (LAAC group). A control group (non-LAAC group) was formed from 141 NVAF patients without LAAC using propensity score matching. The difference-in-difference analysis was used to evaluate the difference in cardiac remodeling between the two groups at baseline and follow-up evaluations. Results: The LAAC group had a larger increase in LA dimension, volume and volume index than the non-LAAC group (+3.9 mm, p = 0.001; +9.7 mL, p = 0.006 and +5.9 mL/m2, p = 0.011, respectively). Besides, a significant increase in E and E/e’ ratio was also observed in the LAAC group (+14.6 cm/s, p = 0.002 and +2.3, p = 0.028, respectively). Compared with the non-LAAC group, left ventricular (LV) ejection fraction and fractional shortening decreased in LAAC patients, but were statistically insignificant (–3.5%, p = 0.109 and –2.0%, p = 0.167, respectively). Conclusions: There were significant increases in LA size and LV filling pressure among NVAF patients after LAAC. These impacts of LAAC on cardiac functional and structural remodeling may have some clinical implications that need to be addressed in future studies.
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