溶酶体
生物
细胞生物学
mTORC1型
脂质代谢
分解代谢
自噬
生物发生
合成代谢
TFEB
内体
生物化学
信号转导
新陈代谢
PI3K/AKT/mTOR通路
细胞内
基因
酶
细胞凋亡
作者
Ashley M. Thelen,Roberto Zoncu
标识
DOI:10.1016/j.tcb.2017.07.006
摘要
Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and nonvesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the crossroads of this network due to its ability to process and sort exogenous and endogenous lipids. The lipid-sorting function of the lysosome is intimately connected to its recently discovered role as a metabolic command-and-control center, which relays multiple nutrient cues to the master growth regulator, mechanistic target of rapamycin complex (mTORC)1 kinase. In turn, mTORC1 potently drives anabolic processes, including de novo lipid synthesis, while inhibiting lipid catabolism. Here, we describe the dual role of the lysosome in lipid transport and biogenesis, and we discuss how integration of these two processes may play important roles both in normal physiology and in disease.
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