Z-Selective Ruthenium-Catalyzed Olefin Cross Metathesis

Significance Olefin cross-metathesis has found widespread use in bench-scale and process chemistry as a reliable way of forming carbon-­carbon double bonds (see Review below). With few exceptions, the more thermodynamically ­favored E -isomers are produced. The authors demonstrate that, by utilizing a novel chelated ­ruthenium catalyst, selectivity for the Z -isomer can be achieved. Review: G. C. Vougioukalakis, R. H. Grubbs Chem. Rev . 2010 , 110 , 1746-1787.