丁酸盐
胰岛素抵抗
肠道菌群
内科学
胰岛素
内分泌学
胰岛素敏感性
代谢综合征
肥胖
新陈代谢
碳水化合物代谢
生物
医学
胃肠病学
免疫学
食品科学
发酵
作者
Anne Vrieze,Els van Nood,F. Holleman,Jarkko Salojärvi,Ruud S. Kootte,J. F. W. M. Bartelsman,Geesje M. Dallinga‐Thie,Mariëtte T. Ackermans,Mireille J. Serlie,Raish Oozeer,Muriel Derrien,Anne Druesne,Johan E. T. van Hylckama Vlieg,Vincent W. Bloks,Albert K. Groen,Hans G.H.J. Heilig,Erwin G. Zoetendal,Erik S.G. Stroes,Willem M. de Vos,J. B. L. Hoekstra,Max Nieuwdorp
出处
期刊:Gastroenterology
[Elsevier]
日期:2012-10-01
卷期号:143 (4): 913-916.e7
被引量:2293
标识
DOI:10.1053/j.gastro.2012.06.031
摘要
Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 μmol/kg/min; P < .05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).
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