Cognitive deficits of pure subcortical vascular dementia vs Alzheimer disease

波士顿命名测验 痴呆 神经心理学 心理学 高强度 血管性痴呆 口语流利性测试 试制试验 匹兹堡化合物B 医学 听力学 内科学 疾病 精神科 认知 磁共振成像 放射科
作者
Cindy W. Yoon,Ji Soo Shin,Han Jo Kim,Hanna Cho,Young Noh,Geon Ha Kim,Juhee Chin,Seung Jun Oh,Jae Seung Kim,Yearn Seong Choe,Kyung-Han Lee,Jae‐Hong Lee,Sang Won Seo,Duk L. Na
出处
期刊:Neurology [Lippincott Williams & Wilkins]
卷期号:80 (6): 569-573 被引量:47
标识
DOI:10.1212/wnl.0b013e3182815485
摘要

Despite many neuropsychological studies to differentiate subcortical vascular dementia (SVaD) from Alzheimer disease (AD), previous studies did not eliminate confounding effects of mixed Alzheimer and vascular pathology. We aimed to investigate neuropsychological differences between patients with Pittsburgh compound B (PiB)-negative SVaD and those with PiB-positive AD.We recruited patients who were clinically diagnosed with SVaD or AD and underwent an 11C-PiB-PET scan. All patients with SVaD fulfilled DSM-IV criteria for vascular dementia and had severe white matter hyperintensities. The diagnosis of AD was made on the basis of criteria for probable AD proposed by the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association.The final patient sample consisted of 44/67 (65.7%) patients with SVaD who tested negative for PiB retention [PiB- SVaD] and 61/68 (89.7%) patients with AD who tested positive for PiB retention [PiB(+) AD]. Patients with PiB- SVaD performed better than patients with PiB(+) AD on both verbal and visual memory tests including delayed recalls of the Seoul verbal learning test and Rey complex figure test. Patients with PiB- SVaD were worse than patients with PiB(+) AD on phonemic fluency of the Controlled Oral Word Association Test and Stroop color test.Patients with PiB- SVaD were better at memory but worse at frontal function than patients with PiB(+) AD. The differences in memory/frontal functions observed between the 2 groups, however, could not differentiate all individual data due to some overlap in the cutoff threshold.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
SciGPT应助zhy采纳,获得10
刚刚
1秒前
1秒前
吴宵发布了新的文献求助10
1秒前
lehha完成签到,获得积分10
1秒前
2秒前
iNk应助冰山泥采纳,获得20
2秒前
diraczh发布了新的文献求助10
3秒前
聪明飞飞完成签到,获得积分10
3秒前
123456qi发布了新的文献求助10
3秒前
power完成签到,获得积分10
3秒前
4秒前
核桃应助bji采纳,获得10
4秒前
4秒前
小马甲应助小张采纳,获得10
5秒前
周大官人完成签到,获得积分10
5秒前
jokerli完成签到,获得积分10
5秒前
joey2024发布了新的文献求助10
6秒前
可爱非笑发布了新的文献求助10
6秒前
masirthu发布了新的文献求助10
6秒前
6秒前
7秒前
聪明的鹤完成签到,获得积分10
7秒前
7秒前
四夕完成签到 ,获得积分10
8秒前
Debra完成签到,获得积分10
8秒前
sssss发布了新的文献求助10
9秒前
snnnn完成签到,获得积分20
9秒前
10秒前
中中完成签到,获得积分10
10秒前
人类之光发布了新的文献求助10
10秒前
cdh1994应助90采纳,获得10
10秒前
isle发布了新的文献求助10
11秒前
cangcang完成签到,获得积分10
11秒前
12秒前
Hello应助可爱非笑采纳,获得10
12秒前
机灵柚子应助sssss采纳,获得20
12秒前
cgliuhx发布了新的文献求助10
12秒前
高分求助中
【重要!!请各位用户详细阅读此贴】科研通的精品贴汇总(请勿应助) 10000
醤油醸造の最新の技術と研究 1000
Plutonium Handbook 1000
Three plays : drama 1000
Robot-supported joining of reinforcement textiles with one-sided sewing heads 640
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 540
Thermal Quadrupoles: Solving the Heat Equation through Integral Transforms 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4115426
求助须知:如何正确求助?哪些是违规求助? 3653817
关于积分的说明 11570442
捐赠科研通 3357541
什么是DOI,文献DOI怎么找? 1844358
邀请新用户注册赠送积分活动 910067
科研通“疑难数据库(出版商)”最低求助积分说明 826691