医学
骨关节炎
N-末端末端肽
软骨
生物标志物
内科学
骨重建
代理终结点
肿瘤科
C反应蛋白
入射(几何)
生物信息学
炎症
病理
骨钙素
碱性磷酸酶
物理
酶
化学
替代医学
光学
解剖
生物
生物化学
作者
Fatemeh Saberi Hosnijeh,Jos Runhaar,Joyce B. J. van Meurs,Sita Bierma‐Zeinstra
出处
期刊:Maturitas
[Elsevier]
日期:2015-09-01
卷期号:82 (1): 36-49
被引量:56
标识
DOI:10.1016/j.maturitas.2015.04.004
摘要
The identification of early biochemical predictors of osteoarthritis (OA) has been the focus of much research over the past few years. However, it still is unclear whether current biochemical markers can be used in prognostic risk assessment of OA. The aim of this systematic review is to evaluate the possible prognostic application of blood and urinary biochemical markers of knee and hip OA. Abstract and full text selection was done by two independent reviewers. A total of 25 relevant publications including 37 biochemical markers of bone and cartilage turnover and inflammation associated with some aspects of OA were reviewed. Most of those biomarkers were studied only once or twice. Due to heterogeneity of both OA-phenotype and determinant among the publications, meta-analysis of the studied biochemical markers was not possible. There was strong evidence for urinary C-terminal telopeptide of collagen type II (uCTX-II) as a prognostic marker for knee OA progression and serum cartilage oligomeric protein (COMP) level as prognostic marker for incidence of knee and hip OA. Evidence for prognostic value of C-reactive protein is still inconclusive. International standardization of future investigations should be pursued to obtain more high-quality, homogenous data on the full spectrum of biochemical OA markers.
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