免疫监视
细胞毒性
免疫系统
生物
自然杀伤细胞
免疫学
受体
抗体依赖性细胞介导的细胞毒性
免疫突触
淋巴因子激活杀伤细胞
癌症
病毒感染
癌症研究
细胞生物学
白细胞介素21
体外
病毒
T细胞
T细胞受体
生物化学
遗传学
作者
Joachim Koch,Alexander Steinle,Carsten Watzl,Ofer Mandelboim
标识
DOI:10.1016/j.it.2013.01.003
摘要
Natural killer (NK) cells are central players in the vertebrate immune system that rapidly eliminate malignantly transformed or infected cells. The natural cytotoxicity receptors (NCRs) NKp30, NKp44, and NKp46 are important mediators of NK cell cytotoxicity, which trigger an immune response on recognition of cognate cellular and viral ligands. Tumour and viral immune escape strategies targeting these receptor-ligand systems impair NK cell cytotoxicity and promote disease. Therefore, a molecular understanding of the function of the NCRs in immunosurveillance is instrumental to discovering novel access points to combat infections and cancer.
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