生物
间充质干细胞
体内
干细胞
干扰素
癌症研究
体外
免疫学
细胞生物学
遗传学
作者
Cheng Xu,Liangyu Lin,Gang Cao,Q Chen,Peishun Shou,Yanfeng Huang,Yu Han,Yu Wang,Yufang Shi
出处
期刊:Oncogene
[Springer Nature]
日期:2013-11-04
卷期号:33 (42): 5047-5052
被引量:40
摘要
Mesenchymal stem cells (MSCs) are a kind of adult stem cells that can be isolated easily from bone marrow, adipose tissue, umbilical cord and many other tissues. MSCs have been shown to specifically migrate to inflammatory sites, including tumors, and hold great promise as tumor-specific vectors to deliver antitumor agents. Interferon-α (IFNα) has been used in clinic to treat various types of tumors; however, because of its short half-life, significant therapeutic effects require high doses that often results in serious side effects. Here, we tested whether MSCs continuingly secreting IFNα can exert a persistent antitumor effect and eliminate the side effects associated with high clinical doses of recombinant IFNα. We found that even a small number of IFNα-secreting MSCs could potently halt B16 tumor growth in vivo. The antitumor activity of IFNα-secreting MSCs was largely abolished in immunodeficient mice, an effect largely attributed to natural killer cells and CD8(+) T cells. Therefore, IFNα-secreting MSCs provide an innovative strategy for tumor therapy.
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