神经递质受体
睡眠剥夺
神经递质
神经科学
睡眠神经科学
受体
睡眠(系统调用)
心理学
神经递质系统
信号转导
海马体
生物
内科学
清醒
医学
认知
细胞生物学
中枢神经系统
多巴胺
脑电图
操作系统
计算机科学
作者
Fabio Longordo,Caroline Kopp,Anita Lüthi
标识
DOI:10.1111/j.1460-9568.2009.06719.x
摘要
Abstract Several pieces of evidence suggest that sleep deprivation causes marked alterations in neurotransmitter receptor function in diverse neuronal cell types. To date, this has been studied mainly in wake‐ and sleep‐promoting areas of the brain and in the hippocampus, which is implicated in learning and memory. This article reviews findings linking sleep deprivation to modifications in neurotransmitter receptor function, including changes in receptor subunit expression, ligand affinity and signal transduction mechanisms. We focus on studies using sleep deprivation procedures that control for side‐effects such as stress. We classify the changes with respect to their functional consequences on the activity of wake‐promoting and/or sleep‐promoting systems. We suggest that elucidation of how sleep deprivation affects neurotransmitter receptor function will provide functional insight into the detrimental effects of sleep loss.
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