生物
先天性淋巴细胞
获得性免疫系统
转录因子
细胞生物学
造血
CD8型
T细胞
免疫学
先天免疫系统
免疫
免疫系统
淋巴细胞生成
干细胞
遗传学
基因
作者
Irma Tindemans,Nicolas Serafini,James P. Di Santo,Rudi W. Hendriks
出处
期刊:Immunity
[Elsevier]
日期:2014-08-01
卷期号:41 (2): 191-206
被引量:195
标识
DOI:10.1016/j.immuni.2014.06.006
摘要
The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression. More recently, GATA-3 was shown to contribute to type 2 immunity through regulation of group 2 innate lymphoid cell (ILC2) development and function. Furthermore, during thymopoiesis, GATA-3 represses B cell potential in early T cell precursors, activates TCR signaling in pre-T cells, and promotes the CD4(+) T cell lineage after positive selection. GATA-3 also functions outside the thymus in hematopoietic stem cells, regulatory T cells, CD8(+) T cells, thymic natural killer cells, and ILC precursors. Here we discuss the varied functions of GATA-3 in innate and adaptive immune cells, with emphasis on its activity in T cells and ILCs, and examine the mechanistic basis for the dose-dependent, developmental-stage- and cell-lineage-specific activity of this transcription factor.
科研通智能强力驱动
Strongly Powered by AbleSci AI