荟萃分析
医学
过氧化物酶体增殖物激活受体γ
子群分析
等位基因
疾病
内科学
2型糖尿病
2型糖尿病
单核苷酸多态性
遗传分析
出版偏见
人口
遗传学
遗传关联
生物信息学
糖尿病
基因
基因型
内分泌学
生物
环境卫生
受体
过氧化物酶体
作者
Junyan Li,Xiaohong Niu,Jianbo Li,Qingzhong Wang
出处
期刊:Current Diabetes Reviews
[Bentham Science]
日期:2019-07-31
被引量:3
标识
DOI:10.2174/1573399814666180912130401
摘要
Background: Previous studies suggested that the single nucleotide polymorphisms of Pro12Ala located within the PPARG gene were significantly associated with the T2DM. Recently, the genetic studies on Pro12Ala were conducted in the different ethnic groups and the results of each study were shown to be inconsistent. Moreover, the systematic review has not been updated since 2000. Objective: To further validate the risk of Pro12Ala for T2DM disease based on the genetic data. Methods: The genetic studies on the Pro12Ala in the T2DM were searched in the PubMed and PMC database from January 2000 to October 2017. The meta-analysis was conducted with the CMA software. Results: The meta-analysis collected 14 studies including 20702 cases and 36227 controls. The combined analysis of all studies found that Pro12Ala was shown to be significantly associated with T2DM and the Ala allele played the increasing risks for the disease. Nevertheless, publication bias was detected in the combined analysis. The subgroup analysis indicated that Pro12Ala was found to be significant in the Caucasian and Chinese population. There was no heterogeneity and publication bias in these two groups. Conclusion: The meta-analysis confirmed the evidence that the Pro12Ala was the susceptible variant for the decreasing risks for the T2DM
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