Relationship between the oxidative stress biomarkers and coronary heart disease: Pathogenesis to therapeutic aspects

The pathophysiology of coronary heart disease (CHD) is significantly influenced by oxidative stress and inflammation, which also modify atherosclerosis. A decreased antioxidant defense and an increase in oxidative stress are factors in the development and progression of coronary artery disease. There are many oxidative stress biomarkers in coronary artery disease. However, this article summarised the role of oxidative stress biomarkers such as paraoxonase, nitrotyrosine, glutathione peroxidase, advanced glycation end-products, 8-hydroxydeoxyguanosine, myeloperoxidase, superoxide dismutase, malondialdehyde, isoprostanes, catalase and derivatives of reactive oxidative metabolites in the pathogenesis of CHD. Targeting the causes and consequences of reactive oxygen species by lifestyle changes and pharmacological approaches is part of controlling oxidative stress indicators in CHD.