Gut bacterial vesicles from the E. coliΔaroD mutant extend C. elegans lifespan

While bacterial membrane-derived vesicles (MDVs) are known for immune functions, this study reveals their anti-aging properties. MDVs from E. coli ΔaroD extend lifespan and alleviate aging phenotypes in Caenorhabditis elegans . We identified Novel27, a miRNA-like sRNA in these MDVs, which increases longevity by 32.8% by directly downregulating the target gene unc-13 . These findings reveal a novel MDV-mediated anti-aging mechanism and establish unc-13 as a key regulator of longevity.