Clinicopathological Analysis of 75 Cases of Childhood Lymphoma

Objective To analyze the clinicopathological features of childhood lymphoma.Methods Seventy-five cases of childhood lymphoma were selected from the files in period of 1996 to 2009 year.Pathologic diagnosis and immunophenotype analysis were performed according to the WHO classification for tumors of hematopoietic and lymphoid tissue(2008).Fluorescence in situ hybridization(FISH) were used for detection of the segregation of c-myc gene in Burkitt lymphoma tumor and diffuse large B-cell lymphoma tumor.Results There were 57 cases of male and 18 cases of female in 75 cases of childhood lymphoma,the ration of sex was 3.171,the average age was 8.74 years old.There were 32 cases(42.7%) in lymph node,43 cases(57.3%) in extra-node,there were more cases(29.3%) in gastrointestinal tract.The most common subtypes were Hodgkin lymphoma(13 cases,17.3%),lymphoblastic lymphoma(16 cases,21.3%),anaplastic large cell lymphoma(12 cases,16.0%),Burkitt lymphoma and diffuse large B-cell lymphoma(33 cases,44.0%),small lymphocytic lymphoma(1 case,1.3%).The genetic change of c-myc gene was executived by FISH in cases of Burkitt lymphoma tumor and diffuse large B-cell lymphoma tumor.Eighteen cases of Burkitt lymphoma tumor existed the c-myc gene segregation in 28 cases of Burkitt lymphoma and diffuse large B-cell lymphoma.Conclusions These cases of male are more than those of female.There are more cases in lymph node and gastrointestinal tract.The most common subtypes are Burkitt lymphoma,lymphoblastic lymphoma,Hodgkin lymphoma,anaplastic large cell lymphoma and diffuse large B-cell lymphoma.