Diels-Alder “Click” Reactions

The Diels-Alder reactions can be classified as click reactions because of their simplicity and high yields. The Diels-Alder click reactions have been used for the preparation of complex macromolecules, such as hydrogels and polymers and also for labeling of various biological targets. This review summarizes the recent application of Diels-Alder click reactions in hydrogel synthesis, polymer and material science and also medicinal application of Diels-Alder click reaction. Keywords: Click reaction, Diels-Alder, hydrogels, inverse electron demand Diels-Alder reactions, polymers.