Objective:To observe the effect of Xiaoshihewei Granules on the gastrointestinal motility in mice with gas-trointestinal motility disorders. Methods:Mouse models of gastrointestinal motility disorders were established with L-arginine,nutritional semisolid paste was used to observe the change of ratio and gastric emptying rate. Results:Xiaoshihewei Granules could improve the gastrointestinal motility in mice,and had similar effect with Mosapride group ( P0.05),the recovery of gastrointestinal motility was close to the blank control group (P0.05). Conclusion:Xiaoshihewei Granules can effectively improve the gastrointestinal motility in mice with gastrointestinal motility disorders.