Reprogramming of induced pluripotent stem cells(iPSCs) is an important breakthrough in the field of regenerative medicine recently.It is achieved through transduction of exogenous transcription factors,into somatic cells,reprogramming the somatic cells to embryonic stem cells-like cells with potencies of unlimited proliferation and pluripotent differentiation.IPSCs derived from somatic cells of patients represent a powerful tool for biomedical research and may provide a source for replacement therapies.Here the research progress of iPSCs reprogramming and its medical prospect were emphasized.