Self‐Adhesive and Self‐Sustainable Bioelectronic Patch for Physiological Feedback Electronic Modulation of Soft Organs

Abstract Bionic electrical stimulation (Bio‐ES) aims to achieve personalized therapy and proprioceptive adaptation by mimicking natural neural signatures of the body, while current Bio‐ES devices are reliant on complex sensing and computational simulation systems, thus often limited by the low‐fidelity of simulated electrical signals, and failure of interface information interaction due to the mechanical mismatch between soft tissues and rigid electrodes. Here, the study presents a flexible and ultrathin self‐sustainable bioelectronic patch (Bio‐patch), which can self‐adhere to the lesion area of organs and generate bionic electrical signals synchronized vagal nerve envelope in situ to implement Bio‐ES. It allows adaptive adjustment of intensity, frequency, and waveform of the Bio‐ES to fully meet personalized needs of tissue regeneration based on real‐time feedback from the vagal neural controlled organs. With this foundation, the Bio‐patch can effectively intervene with excessive fibrosis and microvascular stasis during the natural healing process by regulating the polarization time of macrophages, promoting the reconstruction of the tissue‐engineered structure, and accelerating the repair of damaged liver and kidney. This work develops a practical approach to realize biomimetic electronic modulation of the growth and development of soft organs only using a multifunctional Bio‐patch, which establishes a new paradigm for precise bioelectronic medicine.