Underestimated aspects of metformin in the prevention and treatment of prediabetes and type 2 diabetes in the light of modern recommendations

The article discusses the pathogenesis, methods of diagnosis, prevention, and treatment of insulin resistance, prediabetes, and type 2 diabetes. According to international recommendations, the first-line therapy for type 2 diabetes is metformin and lifestyle modification (correction of excess weight, regular physical activity), which have shown high effectiveness in large-scale clinical studies.