间质细胞
巨噬细胞
干细胞
肿瘤微环境
生物
细胞生物学
免疫学
癌症研究
免疫系统
遗传学
体外
作者
Liren Cao,Xiangjun Meng,Zhiren Zhang,Zhonglong Liu,HE Ya
标识
DOI:10.1186/s13578-024-01201-z
摘要
Abstract Macrophages and tumour stroma cells account for the main cellular components in the tumour microenvironment (TME). Current advancements in single-cell analysis have revolutionized our understanding of macrophage diversity and macrophage–stroma interactions. Accordingly, this review describes new insight into tumour-associated macrophage (TAM) heterogeneity in terms of tumour type, phenotype, metabolism, and spatial distribution and presents the association between these factors and TAM functional states. Meanwhile, we focus on the immunomodulatory feature of TAMs and highlight the tumour-promoting effect of macrophage–tumour stroma interactions in the immunosuppressive TME. Finally, we summarize recent studies investigating macrophage-targeted therapy and discuss their therapeutic potential in improving immunotherapy by alleviating immunosuppression.
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